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Identification of mutaprodenafil in a dietary supplement and its subsequent synthesis
Yosuke Demizu1, Daigo Wakana, Hiroyuki Kamakura
1National Institute of Health Sciences, Tokyo, Japan.
Chemical & Pharmaceutical Bulletin
|October 4, 2011
Abstract:
We isolated a new illegal sildenafil analogue named mutaprodenafil from a dietary supplement for erectile dysfunction (ED) and proposed that it is an aildenafil derivative containing an imidazole moiety. We subsequently synthesized mutaprodenafil from a thioaildenafil and authenticated its structure.

