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Updated: Jul 7, 2026

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
rac-1-(2-{[(Benz-yloxy)carbon-yl]amino}-cyclo-hex-yl)pyrrolidin-1-ium chloride
Yoshimi Ichimaru1, Masaaki Kurihara1
1Faculty of Pharmaceutical Sciences Shonan University of Medical Sciences, 16-10 Kamishinano Totsuka-ku Yokohama Kanagawa 244-0806 Japan.
Abstract:
The crystal structure of C19H26N2O2 +·Cl-, an inter-mediate in the synthesis of the selective κ-opioid receptor agonist U50,488, is reported. The compound crystallizes as a centrosymmetric structure with both (S,S)- and (R,R)-enanti-omers in the unit cell. In the crystal, the chloride ion facilitates the formation of enanti-omeric pairs through N-H⋯Cl hydrogen bonds involving both pyrrolidine and the carbamate nitro-gen atoms.
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