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In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses
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Ultrathin side-viewing needle probe for optical coherence tomography.

D Lorenser1, X Yang, R W Kirk

  • 1Optical+Biomedical Engineering Laboratory, School of Electrical, Electronic & Computer Engineering, The University of Western Australia, WA 6009, Australia. dirk.lorenser@uwa.edu.au

Optics Letters
|October 4, 2011
PubMed
Summary
This summary is machine-generated.

Researchers developed the smallest side-viewing needle probe for optical coherence tomography (OCT). This miniaturized probe enables high-resolution 3D imaging of biological tissues, including lung structures.

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Area of Science:

  • Biomedical Engineering
  • Optical Imaging
  • Medical Devices

Background:

  • Optical Coherence Tomography (OCT) is a valuable imaging modality for visualizing subsurface tissue microstructures.
  • Existing OCT probes often lack the miniaturization required for minimally invasive in vivo applications.
  • Developing smaller probes is crucial for advancing endoscopic and interstitial imaging techniques.

Purpose of the Study:

  • To design, fabricate, and characterize the smallest reported side-viewing needle probe for OCT.
  • To evaluate the performance of the miniaturized probe in biological tissues.
  • To demonstrate the feasibility of using the probe for high-resolution 3D imaging.

Main Methods:

  • A 30-gauge (0.31 mm outer diameter) all-fiber needle probe was designed and fabricated.
  • An angle-polished and reflection-coated fiber tip served as the beam deflector.
  • The probe was characterized optically and interfaced with an 840 nm spectral-domain OCT system.
  • Biological tissue imaging was performed, including 3D OCT of lamb lungs.

Main Results:

  • The needle probe achieved extreme miniaturization.
  • In biological tissue, the probe exhibited a working distance of 300 μm and a depth-of-field of 550 μm.
  • The OCT system with the needle probe showed a sensitivity loss of only 7 dB compared to a standard configuration.
  • High-resolution 3D OCT images of lamb lungs revealed individual alveoli and bronchioles.

Conclusions:

  • The developed side-viewing needle probe is the smallest reported for OCT.
  • The probe enables high-resolution, minimally invasive 3D imaging of biological tissues.
  • This technology holds potential for advanced diagnostic and interventional procedures.