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Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
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New hope for type 2 diabetics: targeting insulin resistance through the immune modulation of stem cells

Yong Zhao1, Zhaoshun Jiang, Chengshan Guo

  • 1Section of Endocrinology, Diabetes & Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA. yongzhao@uic.edu

Autoimmunity Reviews
|October 4, 2011
PubMed

The prevalence of type 2 diabetes (T2D) is increasing worldwide, highlighting the need for a better understanding of the pathogenesis of the disease and the development of innovative therapeutic approaches for the prevention and cure of the condition. Mounting evidence points to the involvement of immune dysfunction in insulin resistance in T2D, suggesting that immune modulation may be a useful tool in treating the disease. Recent advances in the use of adult stem cells from human umbilical cord blood and bone marrow for immune modulation hold promise for overcoming immune dysfunction in T2D without many of the complications associated with traditional immunosuppressive therapies. This review focuses on recent progress in the use of immune modulation in T2D and discusses the potential for future therapies. New insights are provided on the use of cord blood-derived multipotent stem cells (CB-SC) in T2D.

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