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Related Concept Videos

Introduction to Language of Pathophysiology l01:25

Introduction to Language of Pathophysiology l

Pathophysiology investigates how biological mechanisms—typically starting at the cellular level—disrupt normal bodily functions. It bridges anatomy and physiology to explain the progression of disease. With this foundation, it is important to understand the following key terms used to describe disease processes: Diagnosis:The process of identifying a disease using clinical evaluation, including signs (objective evidence like rashes), symptoms (subjective experiences like pain), laboratory test...
Introduction to Language of Pathophysiology ll01:17

Introduction to Language of Pathophysiology ll

This lesson explores key terms that describe how diseases progress, their outcomes, and their distribution in populations.Diagnostic tests identify diseases and monitor treatment. These include blood and urine tests, biopsies, imaging (X-ray, MRI), and detection of infectious agents.Remission is a reduction or disappearance of symptoms.Exacerbation refers to the worsening of symptoms, such as increased wheezing during an asthma attack.A precipitating factor triggers an acute episode, while a...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...

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Related Experiment Video

Updated: May 28, 2026

Isolation and Time-Lapse Imaging of Primary Mouse Embryonic Palatal Mesenchyme Cells to Analyze Collective Movement Attributes
07:13

Isolation and Time-Lapse Imaging of Primary Mouse Embryonic Palatal Mesenchyme Cells to Analyze Collective Movement Attributes

Published on: February 13, 2021

Palatogenesis: engineering, pathways and pathologies.

Benjamin Levi1, Samantha Brugman, Victor W Wong

  • 1Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery, Plastic and Reconstructive Surgery Division, Stanford University School of Medicine, Stanford, California, USA.

Organogenesis
|October 4, 2011
PubMed
Summary
This summary is machine-generated.

Cleft palate is a common birth defect requiring surgical repair. This review explores palate development and molecular pathways to advance tissue engineering and treatments for cleft palate.

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Related Experiment Videos

Last Updated: May 28, 2026

Isolation and Time-Lapse Imaging of Primary Mouse Embryonic Palatal Mesenchyme Cells to Analyze Collective Movement Attributes
07:13

Isolation and Time-Lapse Imaging of Primary Mouse Embryonic Palatal Mesenchyme Cells to Analyze Collective Movement Attributes

Published on: February 13, 2021

Method of Studying Palatal Fusion using Static Organ Culture
04:58

Method of Studying Palatal Fusion using Static Organ Culture

Published on: September 19, 2015

Isolation of Whole Cell Protein Lysates from Mouse Facial Processes and Cultured Palatal Mesenchyme Cells for Phosphoprotein Analysis
07:26

Isolation of Whole Cell Protein Lysates from Mouse Facial Processes and Cultured Palatal Mesenchyme Cells for Phosphoprotein Analysis

Published on: April 1, 2022

Area of Science:

  • Developmental Biology
  • Regenerative Medicine
  • Craniofacial Surgery

Background:

  • Cleft palate is a frequent congenital anomaly with significant lifelong challenges.
  • Genetic factors are implicated, but the etiology of most cases remains unknown.
  • Current treatments often involve multiple surgeries, highlighting the need for improved therapeutic strategies.

Purpose of the Study:

  • To review human and mouse models of palate development.
  • To elucidate molecular pathways involved in normal and abnormal palate formation.
  • To explore the potential of tissue engineering for cleft palate repair.

Main Methods:

  • Comprehensive literature review of cleft palate development and molecular pathways.
  • Analysis of studies utilizing human and mouse models.
  • Examination of current and emerging tissue engineering approaches.

Main Results:

  • Transforming growth factor beta superfamily is a key pathway in palate development.
  • Mouse models are predominantly used in cleft palate research and tissue engineering studies.
  • Limited human randomized controlled trials and tissue engineering applications exist for cleft palate repair.

Conclusions:

  • Understanding palate development pathways is crucial for advancing cleft palate treatments.
  • Tissue engineering holds promise for future regenerative therapies for cleft palate.
  • Further research integrating basic science findings into clinical applications is warranted.