[Antibiotic prophylaxis with sulbactam/ampicillin in colon surgery]

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Updated: Oct 29, 2026

Colon Ascendens Stent Peritonitis (CASP) - a Standardized Model for Polymicrobial Abdominal Sepsis
06:45

Colon Ascendens Stent Peritonitis (CASP) - a Standardized Model for Polymicrobial Abdominal Sepsis

Published on: December 18, 2010

D Gui1, G Anastasio, M Pescatori

  • 1Università Cattolica del Sacro Cuore, Roma Instituto di Clinica Chirurgica.

Minerva Chirurgica
|April 15, 1990
PubMed

Insights

Sulbactam/ampicillin effectively prevents surgical site infections in elective colic surgery. This antibiotic regimen demonstrated good tolerability and a low infection rate in the study group.

Area of Science:

  • Surgical prophylaxis
  • Infectious disease
  • Pharmacology

Background:

  • Surgical site infections (SSIs) are a significant concern in colorectal surgery.
  • Perioperative antibiotic prophylaxis is crucial for reducing SSI rates.
  • Evaluating established antibiotic regimens ensures optimal patient outcomes.

Purpose of the Study:

  • To assess the efficacy of sulbactam/ampicillin as a perioperative prophylactic agent.
  • To determine the safety and tolerability of this regimen in patients undergoing elective colic surgery.
  • To evaluate the incidence of surgical site infections with sulbactam/ampicillin prophylaxis.

Main Methods:

  • An open, non-comparative trial involving 18 patients undergoing elective colic surgery.
  • Sulbactam/ampicillin (S/A) administered pre-operatively and repeated every 6 hours for up to 5 doses.
  • Monitoring for adverse events and recording infection rates.

Main Results:

  • The sulbactam/ampicillin regimen was well tolerated by all patients.
  • No side effects necessitated the interruption of antibiotic prophylaxis.
  • A low infection rate was observed, with only one case of wound suppuration.

Conclusions:

  • Sulbactam/ampicillin serves as an effective and safe perioperative prophylaxis for elective colic surgery.
  • The observed low infection rate supports the use of this regimen in similar surgical procedures.
  • Further large-scale studies could solidify these findings in diverse patient populations.

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