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Poststreptococcal keratouveitis associated with group C streptococcus pharyngitis.

Nathaniel Nataneli¹, Zenia P Aguilera, Pearl S Rosenbaum

¹Department of Ophthalmology, Bronx-Lebanon Hospital Center, Albert Einstein College of Medicine, Bronx, NY, USA.

Clinical Ophthalmology (Auckland, N.Z.)

|October 4, 2011

Summary

This case report details the first instance of poststreptococcal syndrome uveitis (PSU) linked to group C streptococcus (GCS) infection. The findings suggest GCS pharyngitis can be a cause of PSU.

Keywords:

keratolysis keratouveitis pharyngitis

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Area of Science:

Ophthalmology
Infectious Diseases
Rheumatology

Background:

Poststreptococcal syndrome uveitis (PSU) is a known ocular inflammatory condition.
Typically, PSU is associated with Group A Streptococcus (GAS) infections.
The role of other streptococcal groups in PSU pathogenesis remains less understood.

Observation:

A 24-year-old male presented with acute bilateral keratouveitis, photophobia, and conjunctival redness.
Symptoms included a preceding sore throat and fever, along with characteristic "white rings" around the eyes.
Ocular examination revealed bilateral keratouveitis with subsequent peripheral keratolysis.

Findings:

Laboratory tests showed elevated antistreptolysin O (ASLO) titers and C-reactive protein.
Human Leukocyte Antigen B27 (HLA-B27) positivity was noted.
Throat cultures confirmed beta-hemolytic Group C Streptococcus (GCS) and were negative for GAS.

Implications:

This case establishes Group C Streptococcus (GCS) pharyngitis as a potential cause of poststreptococcal syndrome uveitis (PSU).
Highlights the importance of considering non-GAS streptococci in the etiology of PSU.
Suggests broader diagnostic considerations for uveitis following pharyngeal infections.