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ABC Transporters: Importer

ABC Transporters: Importer

ATP-binding cassette or ABC transporters are a class of ATP-driven pumps that hydrolyze ATP to move solutes across the membrane. They can be grouped into importers and exporters. While exporters are present in all domains of life, importers exist only in bacteria and some plants.
In bacteria, based on the number of transmembrane helices and the chemical nature of their substrates, the ABC importers can be divided into three types:

ABC Transporters: Exporter

ABC Transporters: Exporter

ATP-binding cassette or ABC transporter is the largest superfamily of integral membrane proteins. The transporters have transmembrane-binding domains (TMDs) and nucleotide-binding domains (NBDs). The TMDs are specific to their substrates, whereas the NBDs are similar to engines that complete ATP hydrolysis to complete the substrate transport. They can be full transporters consisting of two TMDs and NBDs, half transporters with one TMD and NBD, while some encoded with a single TMD or NBD are...

Antibiotic Selection

Antibiotic Selection

Bacterial Translocation and Protein Secretion

Bacterial Translocation and Protein Secretion

Bacterial protein secretion involves translocation systems to ensure proteins reach their designated locations, including the plasma membrane, periplasm, outer membrane, or the external environment. These translocation systems are vital for bacterial physiology, supporting processes like membrane assembly, enzymatic activity in the periplasm, and interactions with the external environment. The division of labor between Sec and Tat pathways ensures efficiency in handling proteins with diverse...

Transcellular Transport of Solutes

Transcellular Transport of Solutes

Transcellular transport of solutes is the movement of substances like monosaccharides and amino acids through polarized cells. This transport mechanism is primarily seen in epithelial and endothelial cells aided by membrane transport proteins such as channels and transporters. The tight junctions between these cells confine the membrane proteins to the two sides of the cell. The epithelial cells have distinct apical and basolateral domains. In contrast, the endothelial cells show the luminal...

Anoxygenic Phototrophic Bacteria

Anoxygenic Phototrophic Bacteria

Anoxygenic phototrophic bacteria are a diverse group of microorganisms that perform photosynthesis without producing oxygen. They primarily include purple sulfur bacteria, purple nonsulfur bacteria, green sulfur bacteria, and green nonsulfur bacteria. These bacteria are classified into the Gammaproteobacteria, Alphaproteobacteria, Betaproteobacteria, Chlorobi, and Chloroflexi lineages, each with distinct physiological and ecological adaptations.Purple sulfur bacteria belong to the...

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Related Experiment Video

Updated: May 28, 2026

Expression, Solubilization, and Purification of Eukaryotic Borate Transporters

Expression, Solubilization, and Purification of Eukaryotic Borate Transporters

Published on: March 7, 2019

ABC solute importers in bacteria.

Jinming Cui¹, Amy L Davidson

¹Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, U.S.A.

Essays in Biochemistry

|October 5, 2011

Summary

Bacterial ATP-binding cassette (ABC) importers are crucial for nutrient uptake and survival. This review details their structure, mechanism, and regulation for a comprehensive understanding.

Area of Science:

Microbiology
Molecular Biology
Biochemistry

Background:

Bacterial ATP-binding cassette (ABC) importers are vital for nutrient acquisition.
These importers are essential for bacterial survival in nutrient-limited conditions, including within the human body.
Despite substrate diversity, ABC importers share conserved structural and mechanistic features.

Purpose of the Study:

To provide a foundational understanding of bacterial ABC importers.
To present current knowledge on the structure, mechanism, and regulation of these proteins.
To highlight the significance of ABC importers in bacterial physiology.

Main Methods:

This chapter synthesizes existing research and literature.
It focuses on structural, mechanistic, and regulatory aspects of ABC importers.

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Last Updated: May 28, 2026

Expression, Solubilization, and Purification of Eukaryotic Borate Transporters

Expression, Solubilization, and Purification of Eukaryotic Borate Transporters

Published on: March 7, 2019

High-Throughput Expression and Purification of Human Solute Carriers for Structural and Biochemical Studies

High-Throughput Expression and Purification of Human Solute Carriers for Structural and Biochemical Studies

Published on: September 29, 2023

In vitro Investigation of the MexAB Efflux Pump From Pseudomonas aeruginosa

In vitro Investigation of the MexAB Efflux Pump From Pseudomonas aeruginosa

Published on: February 17, 2014

No new experimental data were generated.

Main Results:

ABC importers possess a conserved multisubunit architecture.
They utilize ATP hydrolysis for energy to transport diverse substrates.
Key regulatory mechanisms govern their function.

Conclusions:

Bacterial ABC importers are versatile and essential nutrient transporters.
Understanding their structure and mechanism is key to their function.
Further research into their regulation can reveal new insights.