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Histamine in the retina: recent progress and perspectives.
1Department of Biogenic Amines, Polish Academy of Sciences, Lodz.
Agents and Actions
|April 1, 1990
Summary
Histamine (HA) systems in vertebrate retinas are comparable to the brain, with species-specific variations. Light exposure impacts retinal HA parameters in rabbits, suggesting HA
Area of Science:
- Neuroscience
- Ophthalmology
- Pharmacology
Background:
- Histamine (HA) is a neurotransmitter found in the brain.
- Its role in the retina is less understood.
- Vertebrate retinas and brains were analyzed for histaminergic system comparisons.
Purpose of the Study:
- To compare histaminergic systems in vertebrate retinas and brains.
- To investigate the physiological role of histamine in the retina.
Main Methods:
- Analysis of histamine levels, enzyme activities (histidine decarboxylase, HA-methyltransferase), release and uptake.
- 3H-mepyramine binding assays.
- Assessment of histamine's effect on cAMP accumulation and diurnal variations.
Main Results:
- Histaminergic systems in vertebrate retinas and brains show similarities.
- Species-dependent differences in retinal histamine parameters were observed.
- Light exposure selectively altered histaminergic parameters in rabbit retinas, but not brains.
Conclusions:
- Histaminergic systems in the retina and brain are comparable across vertebrates.
- Histamine (HA) may play a significant physiological role in the retinas of certain vertebrates.
- Light-induced changes highlight the retina-specific functions of histaminergic signaling.