Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Gene Therapy

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...

Gene Therapy

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...

Angle Closure Glaucoma: Treatment

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

Open Angle Glaucoma: Treatment

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

Glaucoma: Overview

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Practices in the Management of Incidental Gallbladder Cancer.

South Asian journal of cancer·2024

Same author

The projected impact of the inflation reduction act's climate provisions on cardiovascular and respiratory outcomes.

American journal of preventive cardiology·2024

Same author

Current Pediatric Endoscopy Training Situation in the Asia-Pacific Region: A Collaborative Survey by the Asian Pan-Pacific Society for Pediatric Gastroenterology, Hepatology and Nutrition Endoscopy Scientific Subcommittee.

Pediatric gastroenterology, hepatology & nutrition·2024

Same author

Method validation, residue behaviour and dietary risk assessment of insecticides (cyantraniliprole, acetamiprid, flubendiamide and its metabolite, des-iodo flubendiamide) in or on broccoli using LC-MS/MS.

Biomedical chromatography : BMC·2024

Same author

Dissipation kinetics and the evaluation of dietary risks associated with deltamethrin, ethion, fenazaquin, and fenpropathrin on bell pepper (Solanum annuum L.).

Environmental geochemistry and health·2024

Same author

Estimation of rice yield using multivariate analysis techniques based on meteorological parameters.

Scientific reports·2024

Search research articles

Related Experiment Video

Updated: May 28, 2026

Adenoviral Gene Therapy for Diabetic Keratopathy: Effects on Wound Healing and Stem Cell Marker Expression in Human Organ-cultured Corneas and Limbal Epithelial Cells

Adenoviral Gene Therapy for Diabetic Keratopathy: Effects on Wound Healing and Stem Cell Marker Expression in Human Organ-cultured Corneas and Limbal Epithelial Cells

Published on: April 7, 2016

Gene therapy in the cornea: 2005--present.

Rajiv R Mohan¹, Jonathan C K Tovey, Ajay Sharma

¹Harry S. Truman Memorial Veterans' Hospital, 800 Hospital Drive, Columbia, MO 65201, USA. mohanr@health.missouri.edu

Progress in Retinal and Eye Research

|October 5, 2011

Summary

Gene therapy shows promise for treating corneal blindness by delivering therapeutic genes. Advances in vectors and techniques are overcoming challenges for treating various corneal disorders.

More Related Videos

Three Strategies to Induce Neurotrophic Keratitis and Nerve Regeneration in Murine Cornea

Three Strategies to Induce Neurotrophic Keratitis and Nerve Regeneration in Murine Cornea

Published on: December 8, 2023

Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation

Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation

Published on: November 17, 2014

Related Experiment Videos

Last Updated: May 28, 2026

Adenoviral Gene Therapy for Diabetic Keratopathy: Effects on Wound Healing and Stem Cell Marker Expression in Human Organ-cultured Corneas and Limbal Epithelial Cells

Adenoviral Gene Therapy for Diabetic Keratopathy: Effects on Wound Healing and Stem Cell Marker Expression in Human Organ-cultured Corneas and Limbal Epithelial Cells

Published on: April 7, 2016

Three Strategies to Induce Neurotrophic Keratitis and Nerve Regeneration in Murine Cornea

Three Strategies to Induce Neurotrophic Keratitis and Nerve Regeneration in Murine Cornea

Published on: December 8, 2023

Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation

Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation

Published on: November 17, 2014

Area of Science:

Ophthalmology
Molecular Biology
Biotechnology

Background:

Gene therapy offers a promising approach for treating ocular diseases and disorders.
The cornea is an accessible and immune-privileged tissue, making it an ideal target for gene therapy.
Significant advancements in corneal gene therapy have been observed in the last five years.

Purpose of the Study:

To provide an update on developments in gene therapy for corneal diseases.
To discuss the potential of gene-based interventions for corneal abnormalities.
To identify barriers hindering the utilization of gene therapy for corneal applications.

Main Methods:

Review of recent progress in gene transfer vectors and techniques for corneal gene therapy.
Assessment of therapeutic gene delivery for corneal diseases caused by various injuries.
Analysis of experimental animal models for controlling corneal disorders like fibrosis and angiogenesis.

Main Results:

Next-generation viral and nanoparticle vectors have been identified.
Characterization of gene levels, localization, and duration in the cornea has improved.
Successful control of corneal disorders in animal models with minimal side effects has been demonstrated.

Conclusions:

Gene therapy is progressing towards clinical application for corneal blindness.
Further research is needed to overcome existing barriers for widespread gene therapy utilization in the cornea.
Therapeutic gene delivery holds potential for treating a range of corneal conditions resulting from injury and abnormal healing.