Oregano extract ointment for wound healing: a randomized, double-blind, petrolatum-controlled study evaluating...

Area of Science:

• Dermatology
• Natural Products Research
• Wound Care

Background:

• Wound healing is complex, influenced by hydration, bacteria, and inflammation.
• Oregano possesses significant antibacterial, antifungal, antioxidant, and anti-inflammatory properties.
• Limited research exists on oregano ointment's impact on wound healing.

Purpose of the Study:

• To evaluate the efficacy of a 3% oregano extract ointment in promoting wound healing.
• To assess the impact of oregano ointment on bacterial contamination and scar quality post-surgery.

Main Methods:

• A randomized, double-blind, petrolatum-controlled trial involving 40 surgical patients.
• Bacterial cultures were taken on day 12 post-surgery.
• Scar assessment using the Patient and Observer Scar Assessment tool at 12, 45, and 90 days.

Main Results:

• Oregano ointment group showed a 19% rate of Staphylococcus aureus positive cultures versus 41% in the petrolatum group.
• Fewer infections (cellulitis) occurred in the oregano group (1 patient) compared to the petrolatum group (3 patients).
• Statistically significant improvements in scar color, pigmentation, and pliability were observed with oregano ointment.

Conclusions:

• Oregano extract ointment effectively reduces bacterial contamination and subsequent infection in post-surgical wounds.
• The ointment demonstrated comparable overall scar appearance to petrolatum.
• Oregano extract shows promise as a topical agent for enhancing wound healing and improving scar outcomes.