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Updated: May 28, 2026

Models of Bone Metastasis
Published on: September 4, 2012
[Hypophosphatemia and tumor-induced osteomalacia]
C van der Rest1, E Cavalier, L Colson
1Département de médecine nucléaire, CHU Sart-Tilman, Université de Liège, Liège, Belgique. catherinevanderrest@hotmail.com
Abstract:
In this article, we will discuss about hypophosphatemia due to tumor-induced osteomalacia. This disease is characterized by severe muscular and articular tenderness inducing profound walking limitation. Clinical chemistry results show severe hypophosphatemia due to hyperphosphaturia. Fibroblast growth factor 23 (FGF-23) is abnormally high. Physiological role of FGF-23 is examined. We also consider the pathophysiology of tumor induced osteomalacia, the use of different investigations to localize the tumor and therapies available to treat this rare disease.
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