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Two new compounds from Comastoma pedunlulatum.

Li Tang1, Xiao-Ming Xu, Kirsten Alison Rinderspacher

  • 1Division of Experimental Therapeutics, Department of Medicine, Columbia University, New York, NY 10032, USA.

Journal of Asian Natural Products Research
|October 7, 2011
PubMed
Summary

Two novel compounds, a xanthonoid and a flavonoid C-glycoside, were identified in Comastoma pedunlulatum. Their structures were determined using spectroscopic and physicochemical analyses.

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Area of Science:

  • Phytochemistry
  • Natural Product Chemistry
  • Pharmacognosy

Background:

  • Comastoma pedunlulatum is a plant species with potential medicinal properties.
  • Natural products are a rich source of novel chemical structures with diverse biological activities.

Purpose of the Study:

  • To isolate and characterize new chemical compounds from Comastoma pedunlulatum.
  • To elucidate the structures of these novel compounds using advanced analytical techniques.

Main Methods:

  • Extraction of dried herb of Comastoma pedunlulatum using ethyl acetate.
  • Isolation of compounds using chromatographic techniques.
  • Structure elucidation through spectroscopic methods (e.g., NMR, MS) and physicochemical properties.

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Main Results:

  • Isolation of two new compounds: a xanthonoid (1) and a flavonoid C-glycoside (2).
  • Compound 1 identified as 1,8-dihydroxy-3,5-dimethoxyxanthone 1-O-[2-(4'-hydroxy-3',5'-dimethoxy-E-cinnamoyl)]-β-D-xylopyranosyl-(1-6)-β-D-glucopyranoside.
  • Compound 2 identified as 6″-O-acetylisoorientin.

Conclusions:

  • The study successfully identified and characterized two previously unknown compounds from Comastoma pedunlulatum.
  • The findings contribute to the understanding of the phytochemical profile of Comastoma pedunlulatum.