Related Experiment Video
Updated: Feb 7, 2026
05:56
Exploring Caspase Mutations and Post-Translational Modification by Molecular Modeling Approaches
Published on: October 13, 2022
1.8K
Designed post-self-assembly structural and functional modifications of a truncated tetrahedron
Yao-Rong Zheng1, Wen-Jie Lan, Ming Wang
1Department of Chemistry, University of Utah, 315 South 1400 East, Room 2020, Salt Lake City, Utah 84112, USA. zhengyaorong@gmail.com
Journal of the American Chemical Society
|October 7, 2011
Summary
Researchers developed post-self-assembly modifications for metal-organic supramolecular structures. These efficient chemical stimuli-driven changes alter components, structure, and function, offering new material properties.
Area of Science:
- Supramolecular Chemistry
- Materials Science
- Chemical Synthesis
Background:
- Discrete metal-organic supramolecular structures offer tunable properties.
- Modifying these structures post-assembly presents a challenge for property tuning.
Purpose of the Study:
- To develop efficient methods for post-self-assembly modification of metal-organic supramolecular structures.
- To demonstrate control over structural and functional properties through chemical stimuli.
Main Methods:
- Application of chemical stimuli to induce modifications.
- Characterization using NMR spectroscopy, UV-vis spectroscopy, mass spectrometry, pulsed field gradient spin echo NMR, and electrochemical analysis.
- Computational simulations to understand structural changes.
Main Results:
- Achieved >90% yield in post-assembly modifications.
- Demonstrated three distinct modification types: building-block change, structural alteration, and functional evolution.
- Successfully modified a [6+4] metal-organic supramolecular structure.
Conclusions:
- Post-self-assembly chemical modifications provide a versatile route to tune supramolecular properties.
- This approach enables precise control over component, structure, and function.
- The developed methods are efficient and broadly applicable to discrete supramolecular systems.
More Related Videos
Related Concept Videos
01:56Structural Protein Function
30.0K
Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity. In bones and teeth, it mineralizes to...
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity. In bones and teeth, it mineralizes to...
30.0K
01:32Assembly of Complex Microtubule Structures
2.5K
Complex microtubule structures are present in resting cells and in dividing cells. In resting cells, they are responsible for maintaining the cellular architecture, tracks for intracellular transport, positioning of organelles, assembly of cilia and flagella. They mediate the bipolar spindle assembly for chromosomal segregation and positioning of the cell division plate in dividing cells. The formation of microtubule complex structures depends on the cell type, cell stage, and cell function.
2.5K
01:09Truncation in Survival Analysis
622
Truncation in survival analysis refers to the exclusion of individuals or events from the dataset based on specific criteria related to the time of the event. This exclusion can happen in two primary forms: left truncation and right truncation.
Left truncation occurs when individuals who experienced the event of interest before a certain time are not included in the study. This is often due to a "delayed entry" into the study where only those who survive until a certain entry point are...
Left truncation occurs when individuals who experienced the event of interest before a certain time are not included in the study. This is often due to a "delayed entry" into the study where only those who survive until a certain entry point are...
622
02:10Additional Subnuclear Structures
5.4K
The eukaryotic nucleus is a double membrane-bound organelle that contains nearly all of the cell’s genetic material in the form of chromosomes. It is rightly called the “brain” of the cell as it shoulders the responsibility of responding to various physiological processes, stress, altered metabolic conditions, and other cellular signals.
The nucleus contains many membrane-less subnuclear organelles or nuclear bodies, such as nucleoli, Cajal bodies, speckles,...
The nucleus contains many membrane-less subnuclear organelles or nuclear bodies, such as nucleoli, Cajal bodies, speckles,...
5.4K
01:58Fruit Development, Structure, and Function
25.3K
Fruits form from a mature flower ovary. As seeds develop from the ovules contained within, the ovary wall undergoes a series of complex changes to form fruit. In some fruits, such as soybeans, the ovary wall dries; in other fruits, such as grapes, it remains fleshy. In some cases, organs other than the ovary contribute to fruit formation; such fruits are called accessory fruits.
25.3K
02:25Spreading of Chromatin Modifications
9.5K
The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
The writer...
Writers
The writer...
9.5K