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Related Experiment Video

Updated: May 28, 2026

Transmembrane Domain Oligomerization Propensity determined by ToxR Assay

Transmembrane Domain Oligomerization Propensity determined by ToxR Assay

Published on: May 26, 2011

Transistor-like behavior of single metalloprotein junctions.

Juan M Artés¹, Ismael Díez-Pérez, Pau Gorostiza

¹Institute for Bioengineering of Catalonia (IBEC), Baldiri Reixac 15-21, Barcelona 08028 Spain.

|October 7, 2011

Summary

We measured the electrical conductance of single azurin proteins, finding it to be 7.3 × 10(-6)G(0). This work demonstrates a single redox protein field-effect transistor using electrochemical tunneling microscopy.

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Area of Science:

Molecular electronics
Biophysics
Nanotechnology

Background:

Single protein junctions are crucial for molecular electronics.
Understanding electron transport through proteins is key for bio-electronic devices.

Purpose of the Study:

To measure the electrical conductance of single azurin protein molecules.
To demonstrate the feasibility of a single redox protein field-effect transistor.

Main Methods:

Fabrication of single azurin protein junctions between a gold substrate and an electrochemical tunneling microscope (ECSTM) probe.
Conductance measurements of multiple protein junctions.
Redox gating experiments to control protein conductivity.

Main Results:

Obtained stable single protein junctions using two independent methods.
Measured protein conductance of (7.3 ± 1.5) × 10(-6)G(0).
Demonstrated redox gating with an on/off ratio of 20.

Conclusions:

The measured conductance aligns with previous estimates.
The results prove the concept of a single redox protein field-effect transistor.
This study opens avenues for protein-based electronic components.