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Updated: May 28, 2026

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Published on: December 15, 2023
Association between IL28B polymorphisms and first-phase viral load decrease in chronic hepatitis C virus-infected
Joop E Arends1, Justin H Fransen, Andy I M Hoepelman
1Department of Internal Medicine and Infectious Diseases, University Medical Center Utrecht, Heidelberglaan 100, PO Box 85500, 3508 GA Utrecht, The Netherlands. j.e.arends@umcutrecht.nl
Abstract:
Host polymorphisms in the IL28B region have recently been associated with outcome of treatment for hepatitis C virus (HCV) infection. This study clearly shows an association between first-phase viral load decrease and the IL28B rs12979860 polymorphism in chronic HCV-infected patients. Furthermore, a higher treatment efficiency factor (ɛ) was found in those HCV-infected patients with a CC genotype compared with those with a CT and TT genotype. This study highlights the importance of host response mechanisms in relation to favourable clearance of HCV.
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