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Updated: May 28, 2026

Rapid Nanoprobe Signal Enhancement by In Situ Gold Nanoparticle Synthesis
Published on: March 7, 2018
A novel route to copper(II) detection using 'click' chemistry-induced aggregation of gold nanoparticles
Carol Hua1, William H Zhang, Swahnnya R M De Almeida
1School of Chemistry, The University of New South Wales, Sydney, NSW 2052, Australia.
Abstract:
A simple colorimetric method for the detection of copper ions in water is described. This method is based on the 'click' copper(I)-catalyzed azide-alkyne cycloaddition reaction and its use in promoting the aggregation of azide-tagged gold nanoparticles by a dialkyne cross-linker is described. Nanoparticle cross-linking, evidenced as a colour change, is used for the detection of copper ions. The lowest detected concentration by the naked eye was 1.8 μM, with the response linear with log(concentration) between 1.8-200 μM. The selectivity relative to other potentially interfering ions was evaluated.
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