Related Experiment Video
Updated: May 28, 2026

Methods for ECG Evaluation of Indicators of Cardiac Risk, and Susceptibility to Aconitine-induced Arrhythmias in Rats Following Status Epilepticus
Published on: April 5, 2011
Pyrilamine-induced prolonged QT interval in adolescent with drug overdose
Govinda Paudel1, Muhammad Syed, Sarika Kalantre
1Division of Pediatric Cardiology and Emergency Medicine, Department of Pediatrics, Lincoln Medical and Mental Health Center, Bronx, NY, USA.
Abstract:
The widespread availability of antihistamines in many over-the-counter preparations can lead to significant hazard to the public because of their possible link to potential ventricular arrhythmias secondary to prolongation of QT interval. The effect can be further compounded by the use of other commonly used medications such as macrolides, antifungal agents, antipsychotics, and other antihistamine-containing preparations. The effect of antihistamines on QT interval is not a class effect but is unique to certain medications. Pyrilamine, a first-generation antihistaminic agent, is considered safe as there are no reports regarding its cardiac toxicity available in literature. We report a case of an adolescent with prolonged QT interval after an overdose of pyrilamine.
Related Concept Videos
Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance
A study on guinea pigs examined the...
Antiarrhythmic Drugs: Class III Agents as Potassium Channel Blockers
Desensitization and Tachyphylaxis
Several...
Drugs Affecting Neurotransmitter Release or Uptake
Antiepileptic Drugs: Potassium Channel Activators
Ezogabine has gained approval as an adjunctive treatment...
Antiarrhythmic Drugs: Class II Agents as β-Adrenergic Blockers

