Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

Imaging Studies for Cardiovascular System IV: CMRI

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...

Imaging Studies IV: Magnetic Resonance Imaging

Imaging Studies IV: Magnetic Resonance Imaging

Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...

Imaging Studies I: CT and MRI

Imaging Studies I: CT and MRI

Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...

Radiological Investigation II: MRI and Ventilation Perfusion Scan

Radiological Investigation II: MRI and Ventilation Perfusion Scan

Description
Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
MRI
MRI uses magnetic fields and radiofrequency signals to distinguish between normal and abnormal tissues. This technology provides a more detailed diagnostic image than CT scans, enabling it to characterize pulmonary nodules, stage bronchogenic carcinoma, and evaluate inflammatory activity in...

Imaging Studies VII: Vascular Imaging

Imaging Studies VII: Vascular Imaging

DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Genotype-stratified Default Mode Network hyperconnectivity in major depressive disorder: an MR imaging genetics study.

Journal of affective disorders·2026

Same author

Quantitative vs Qualitative analysis of breast lesions on dynamic contrast-enhanced Magnetic Resonance Imaging.

La Clinica terapeutica·2026

Same author

Quantification of Liver Stiffness Using Magnetic Resonance Elastography in Comparison with Transient Elastography and Noninvasive Fibrosis Score in Fatty Liver.

The Journal of the Association of Physicians of India·2025

Same author

MR Elastography of Pituitary Macroadenomas with Intraoperative and Immunofluorescence correlation: A Feasibility study along with Literature Review.

La Clinica terapeutica·2025

Same author

Cavernous Sinus Involvement in Rhino-orbital Cerebral Mucormycosis and Impact of Concurrent COVID-19 on Patient Outcome: A Retrospective Observational Study.

The Journal of the Association of Physicians of India·2025

Same author

Magnetic resonance imaging to differentiate between Crohn's disease-associated and cryptoglandular perianal fistula.

Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology·2025

Search research articles

Related Experiment Video

Updated: May 28, 2026

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

Wilson's disease: MRI features.

Paramdeep Singh¹, Archana Ahluwalia, Kavita Saggar

¹Department of Radiodiagnosis, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.

Journal of Pediatric Neurosciences

|October 7, 2011

Summary

This summary is machine-generated.

Wilson's disease, a genetic disorder affecting copper metabolism, was diagnosed in a 15-year-old boy presenting with tremors and speech difficulties. Brain MRI revealed characteristic findings, including the "double panda sign" in the brainstem.

Keywords:

Copper Wilsons double panda sign magnetic resonance imaging

More Related Videos

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease

Published on: December 18, 2016

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Published on: December 9, 2010

Related Experiment Videos

Last Updated: May 28, 2026

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease

Published on: December 18, 2016

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Published on: December 9, 2010

Area of Science:

Neurology
Medical Genetics
Radiology

Background:

Wilson's disease is a rare autosomal recessive genetic disorder.
It is characterized by excessive copper accumulation in organs, primarily the liver and brain.
Neurological and psychiatric symptoms are common presenting features, especially in adolescents.

Purpose of the Study:

To report a case of Wilson's disease in a 15-year-old male.
To highlight the key clinical and neuroimaging findings in this patient.
To emphasize the diagnostic utility of specific MRI findings.

Main Methods:

Clinical presentation and neurological examination of a 15-year-old male.
Biochemical testing including serum ceruloplasmin and urine copper levels.
Brain Magnetic Resonance Imaging (MRI) with specific attention to brainstem and basal ganglia signal abnormalities.

Main Results:

The patient presented with coarse tremors, dysarthric speech, Kayser-Fleischer rings, and dystonic tremor.
Biochemical studies confirmed Wilson's disease.
Brain MRI demonstrated bilateral T2 hyperintensities in the putamen, thalami, and brainstem, with the latter showing the characteristic "double panda sign".

Conclusions:

The
The characteristic "double panda sign" on brain MRI is a key diagnostic indicator for Wilson's disease, particularly in cases with suggestive neurological symptoms and biochemical findings.