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Published on: November 30, 2022
The formulation of polyhedral boranes for the boron neutron capture therapy of cancer
Gianpiero Calabrese1, John J Nesnas, Eugen Barbu
1School of Pharmacy and Chemistry, Kingston University, Kingston-upon Thames KT1 2EE, UK. G.Calabrese@kingston.ac.uk
Abstract:
The early promise of boron neutron capture therapy as a method for the treatment of cancer has been inhibited by the inherent toxicity associated with therapeutically useful doses of ¹⁰B-containing pharmacophores, the need for target-tissue specificity and the challenges imposed by biological barriers. Although developments in the synthetic chemistry of polyhedral boranes have addressed issues of toxicity to a considerable extent, the optimisation of the transport and the delivery of boronated agents to the site of action--the subject of this review--is a challenge that is addressed by the development of innovative formulation strategies.
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