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Related Experiment Video

Updated: May 28, 2026

Fabrication of Ti3C2 MXene Microelectrode Arrays for In Vivo Neural Recording
09:58

Fabrication of Ti3C2 MXene Microelectrode Arrays for In Vivo Neural Recording

Published on: February 12, 2020

Microelectrode arrays fabricated using a novel hybrid microfabrication method.

Mark W Merlo1, Russell L Snyder, John C Middlebrooks

  • 1Department of Biomedical Engineering, University of California, Irvine, CA 92697, USA.

Biomedical Microdevices
|October 8, 2011
PubMed
Summary

We developed new hybrid microfabrication techniques for microelectrode arrays, combining microwire assembly, MEMS, and micromachining. This method allows for complex designs and improved integration, enabling advanced neural recording devices.

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Area of Science:

  • Neuroscience
  • Materials Science
  • Electrical Engineering

Background:

  • Microelectrode arrays are crucial for neural recording.
  • Existing fabrication methods have limitations in complexity and material choice.

Purpose of the Study:

  • To present novel hybrid microfabrication methods for advanced microelectrode arrays.
  • To demonstrate the fabrication of a 32-channel shank microelectrode array using these techniques.

Main Methods:

  • Combining microwire assembly, microelectromechanical systems (MEMS), and micromachining.
  • Microassembly of insulated gold wires, micromolding, post-molding machining, sacrificial release, and iridium oxide electrodeposition.
  • Fabrication of a 32-channel shank microelectrode array with specific dimensions and electrode site characteristics.

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Last Updated: May 28, 2026

Fabrication of Ti3C2 MXene Microelectrode Arrays for In Vivo Neural Recording
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Published on: February 12, 2020

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
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Main Results:

  • Achieved complex geometries and improved material selection for microelectrodes.
  • Demonstrated high electrode site position accuracy (standard deviation < 4 microm).
  • In vivo recordings showed performance comparable to commercial microelectrode arrays.

Conclusions:

  • The hybrid microfabrication approach enables the creation of sophisticated microelectrode arrays.
  • This method facilitates the development of novel electrodes, including multi-sided, drug-eluting, and biodegradable designs.
  • Advances in microelectrode fabrication pave the way for next-generation neural interfaces.