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Updated: May 28, 2026
Establishment of a Murine Pulp Exposure Model with a Novel Mouth-Gag for Pulpitis Research
Published on: October 27, 2023
In deep cavities stepwise excavation of caries can preserve the pulp
1Faculty of Health Sciences, Department of Cariology and Endodontics, University of Copenhagen, Copenhagen, Denmark.
Data Sources:
Medline and the Igaku Chuo Zasshi (Japanese) databases, the reference list of identified studies and personal reprint collections of authors were searched.
Study Selection:
Randomised controlled trials (RCT), controlled clinical trials (CCT) and case series conducted in permanent teeth were included.
Data Extraction And Synthesis:
Two independent reviewers extracted the data using specially designed forms. A qualitative synthesis is presented.
Results:
Ten English and three Japanese studies were finally included (two RCTs, five CCTs and six case series).
Conclusions:
From this review, stepwise excavation can be concluded as effective for pulp preservation in extremely deep caries where there are no clinical symptoms of irreversible pulpitis. Calcium hydroxide and other materials, such as antimicrobials and polycarboxylate cement combined with tannin fluoride preparation, have been shown to be effective in reducing bacteria after stepwise excavation. Further clinical trials with high levels of study design in this research field are needed to identify the best possible methods for removing carious dentine during stepwise excavation.
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