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Related Experiment Video

Updated: May 28, 2026

A Novel Procedure for Evaluating the Reinforcing Properties of Tastants in Laboratory Rats: Operant Intraoral Self-administration

A Novel Procedure for Evaluating the Reinforcing Properties of Tastants in Laboratory Rats: Operant Intraoral Self-administration

Published on: February 6, 2014

Intravascular food reward.

Albino J Oliveira-Maia¹, Craig D Roberts, Q David Walker

¹Department of Neurobiology, Duke University Medical Center, Durham, North Carolina, United States of America. albinojorgemai@gmail.com

|October 8, 2011

Summary

This summary is machine-generated.

Post-absorptive glucose detection, particularly in the hepatic-portal vein, drives reward responses and dopamine release. This suggests intra-abdominal sensors play a key role in sugar

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A Novel Procedure for Evaluating the Reinforcing Properties of Tastants in Laboratory Rats: Operant Intraoral Self-administration

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Simultaneous Detection of c-Fos Activation from Mesolimbic and Mesocortical Dopamine Reward Sites Following Naive Sugar and Fat Ingestion in Rats

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Studying Food Reward and Motivation in Humans

Studying Food Reward and Motivation in Humans

Published on: March 19, 2014

Area of Science:

Neuroscience
Physiology
Behavioral Science

Background:

Sugar consumption triggers reward pathways and dopamine release, independent of taste.
The exact timing of these effects (pre- or post-absorption) remains unclear.

Purpose of the Study:

To investigate whether post-absorptive glucose detection is sufficient for reward-related responses.
To determine the role of hepatic-portal versus systemic glucose sensing in these effects.

Main Methods:

Rat behavioral conditioning tests with varied glucose administration routes (jugular vein, hepatic-portal vein, enteric).
Measurement of glycemic profiles after glucose administration.
Fast-scan cyclic voltammetry to assess dopamine release in the nucleus accumbens shell.

Main Results:

Glucose administration in the hepatic-portal vein, but not the jugular vein, conditioned robust behavioral responses.
Enteric glucose administration mimicked hepatic-portal glucose effects on glycemic profiles.
Hepatic-portal glucose administration increased dopamine release, unlike jugular administration.

Conclusions:

Post-absorptive glucose effects are sufficient to mediate postingestive behavioral and dopaminergic reward responses.
Hepatic-portal glucose sensing is more critical than systemic glycemia, indicating an intra-abdominal visceral sensor's involvement.