Related Experiment Video
Updated: May 28, 2026

Carotid Artery Infusions for Pharmacokinetic and Pharmacodynamic Analysis of Taxanes in Mice
Published on: October 27, 2014
Acute psychosis after paclitaxel infusion
Nausheen Ahmed1, Saad Usmani, Nicola Jabbour
1Department of Internal Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA. naush2003@yahoo.com
Abstract:
Paclitaxel (PTX) is a widely used antineoplastic agent against a variety of cancers. The common side effects are myelosuppression and peripheral neurotoxicity. There have been occasional instances of central nervous system toxicity after PTX treatment though the syndrome is not well described. We report a patient undergoing treatment for laryngeal cancer who experienced mental status changes and psychosis after each cycle of PTX and carboplatin, lasting for less than a day. In a subsequent cycle excluding PTX, these symptoms did not recur.
Related Concept Videos
Psychosis: Goals of Pharmacotherapy
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
Acute Respiratory Failure-III
Psychosis and Antipsychotic Drugs: Overview
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
Two synthetic agonists of THC,...
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists
Phenothiazines, such as prochlorperazine...
