Contraindications in the use of the periodontal ligament injection

How many times have practitioners used a periodontal ligament injection as a last resort or even in preference to the standard subcutaneous injection? In the past 5 years, the periodontal ligament injection has been implicated in compromising pulpal blood flow, damaging the developing crowns of underlying subcedaneous teeth, causing an increase in systemic absorption of epinephrine from the anesthetic solution, and causing resorption of the cementum. This article discusses some of the disadvantages concerning the periodontal ligament injection in view of some recent research findings.