Related Experiment Video
Updated: May 28, 2026

Optimized Quantitative Assessment of Enhancer RNA Stability in Mouse Embryonic Stem Cells
Published on: November 21, 2025
eNERgizing pluripotent gene transcription
Jean-Pierre Etchegaray1, Raul Mostoslavsky
1The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, USA.
Abstract:
Nucleotide excision repair proteins are classically associated with DNA repair. However, a study by Fong et al. (2011) in the most recent issue of Cell demonstrates that the XPC/RAD23B/CETN2 nucleotide excision repair complex additionally functions as a transcriptional coactivator of Oct4/Sox2, critically regulating maintenance and reestablishment of stem cell pluripotency.
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