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[Thrombolytic therapy using a low dose of tissue plasminogen activator in children]

M J Santiago1, J López-Herce, S Zarzoso

  • 1Servicio de Cuidados Intensivos Pediátricos, Hospital General Universitario Gregorio Marañón, Universidad Complutense de Madrid, España.

Anales De Pediatria (Barcelona, Spain : 2003)
|October 11, 2011
PubMed

Insights

Low-dose tissue plasminogen activator (t-PA) therapy effectively treats acute arterial and venous thrombosis in children, achieving high resolution rates with a low incidence of severe side effects.

Area of Science:

  • Pediatric Thrombosis
  • Thrombolytic Therapy
  • Vascular Medicine

Context:

  • Acute arterial and/or venous thrombosis pose significant risks in pediatric patients.
  • Current treatment guidelines for pediatric thrombosis require careful consideration of efficacy and safety.
  • Tissue plasminogen activator (t-PA) is a potent thrombolytic agent, but its use in children necessitates dose optimization.

Purpose:

  • To evaluate the efficacy and safety of low-dose continuous intravenous tissue plasminogen activator (t-PA) in pediatric patients with acute arterial and/or venous thrombosis.

Summary:

  • A prospective observational study included 18 children (1 month to 11 years) treated with low-dose t-PA (0.01-0.06 mg/kg/h).
  • 94% of patients showed improvement, with 72% complete and 22% partial thrombosis resolution.
  • A low incidence of severe side effects (5%) was observed, with one case of severe hemorrhage.

Impact:

  • Low-dose t-PA therapy demonstrates significant efficacy in treating pediatric acute arterial and/or venous thrombosis.
  • This therapeutic approach offers a favorable safety profile for pediatric patients requiring thrombolysis.
  • Findings support the use of optimized low-dose t-PA regimens in managing pediatric thrombosis.
Abstract

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