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Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity

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Published on: January 7, 2019

Signaling by IL-31 and functional consequences.

Christian Cornelissen¹, Juliane Lüscher-Firzlaff, Jens Malte Baron

¹Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany.

European Journal of Cell Biology

|October 11, 2011

Summary

This summary is machine-generated.

Interleukin-31 (IL-31) is a cytokine crucial for immune responses in the skin and gut. Its dysregulation is linked to inflammatory diseases, suggesting IL-31 as a potential therapeutic target.

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Area of Science:

Immunology
Cellular Biology
Molecular Medicine

Background:

Cytokines mediate cellular communication, with Interleukin-31 (IL-31) identified as a novel member of the IL-6 family.
IL-31 signaling involves a receptor complex (OSMR/IL-31RA) activating key intracellular pathways (JAK-STAT, RAS/ERK, PI3K/AKT).

Purpose of the Study:

To review current knowledge on IL-31 and its receptor, including expression patterns and regulation.
To summarize the role of IL-31 in various diseases and its involvement in immune cell-epithelial interactions.

Main Methods:

Literature review of existing data on IL-31 and its receptor.
Analysis of IL-31's role in human diseases and mouse models.

Main Results:

IL-31 is vital for innate and adaptive immunity in barrier tissues like skin, airways, and the intestine.
Elevated IL-31 expression is associated with pruritic diseases (e.g., atopic dermatitis), allergies, and inflammatory bowel disease.
IL-31 regulates interactions between immune cells (T-cells, mast cells, eosinophils) and epithelial cells.

Conclusions:

IL-31 plays a significant role in the homeostasis of skin, airway, and intestinal epithelia.
IL-31 represents a promising target for novel therapeutic strategies in inflammatory and immune-mediated diseases.