Related Experiment Video
Updated: May 28, 2026

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations
Published on: July 24, 2021
How can we as dentists minimize our contribution to the problem of antibiotic resistance?
1Department of Oral and Maxillofacial Surgery, Baylor College of Dentistry, Texas A&M Health Science Center, 3302 Gaston Avenue, Dallas, TX 75246, USA.
Abstract:
More than 30 million pounds of antibiotics are used in the United States per year, more than 90% for nontherapeutic purposes in animals. Environmental contamination by trace amounts of antibiotics and highly resistant bacteria can lead to resistant infections in humans. Oral and maxillofacial infections are largely mediated by biofilms, which are resistant to antibiotics. Primary treatment is surgical debridement, removal of the cause of the infection, and drainage of pus. Current best practices indicate the use of antibiotics as adjunctive therapy to surgery only when regional, distant, or systemic spread of the infection is a significant risk.
Related Concept Videos
Microbiota Modulation by Antibiotics
Mechanism of Antibiotic Resistance in MRSA
Development of Antibiotic Resistance
Antibiotic Selection
Clinical Significance of Antibiotic Resistance
Gene Regulation in Microbial Communities: Quorum Sensing
