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Updated: May 28, 2026

Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells
Published on: May 19, 2020
Do dental infections really cause central nervous system infections?
Stewart K Lazow1, Steven R Izzo, David Vazquez
1Department of Dental/Oral and Maxillofacial Surgery, Kings County Hospital Center-SUNY Brooklyn, 451 Clarkson Avenue, Brooklyn, NY, USA. skloms@aol.com
Abstract:
In the post-World War I antibiotic era, the prevalence of central nervous system (CNS) infections is estimated to be 1 per 100,000 population. The literature is replete with anecdotal case reports of CNS infections of apparent dental etiology. Conversely, it is widely cited that the incidence of CNS infection of dental etiology is only in the range of 1% to 2%. We seek to answer the question if dental infections really cause CNS infections. In this article, we focus on septic cavernous sinus thrombosis and brain abscess and if it is a diagnosis of exclusion or evidence-based.
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