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Related Experiment Video

Updated: May 28, 2026

Iris Fixation via External Pentagram Suturing

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Published on: May 5, 2022

Bilateral acute iris transillumination.

Ilknur Tugal-Tutkun¹, Sumru Onal, Aylin Garip

¹Department of Ophthalmology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. itutkun@yahoo.com

Archives of Ophthalmology (Chicago, Ill. : 1960)

|October 12, 2011

Summary

A new clinical condition of acute bilateral iris transillumination, pigment dispersion, and pupil issues was identified in 26 patients. This condition, characterized by photophobia and elevated intraocular pressure, is not linked to moxifloxacin use.

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Area of Science:

Ophthalmology
Clinical Science

Background:

A series of patients presented with bilateral acute iris transillumination, pigment dispersion, and sphincter paralysis.
This condition was observed across multiple centers in Turkey and Belgium.

Purpose of the Study:

To describe the clinical characteristics and outcomes of patients with bilateral acute iris transillumination, pigment dispersion, and sphincter paralysis.
To investigate potential causes and associations, including prior antibiotic use.

Main Methods:

Retrospective review of medical records and clinical photographs of 26 patients.
Utilized clinical examination, anterior segment photography, gonioscopy, laser flare photometry, and pupillometry.

Main Results:

All 26 patients exhibited bilateral symptoms, with 88% experiencing acute onset, severe photophobia, and red eyes.
Common findings included iris transillumination, pigment dispersion in the anterior chamber, elevated flare, and compromised pupillary light reaction.
A significant complication was a rapid rise in intraocular pressure, with pigment deposition noted in the trabecular meshwork.

Conclusions:

Bilateral acute iris transillumination with pigment dispersion and persistent mydriasis represents a distinct clinical entity.
The condition is not an adverse effect of oral moxifloxacin, contrary to previous suggestions.
The underlying etiopathogenesis requires further investigation.