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Basic clinical and laboratory features of filoviral hemorrhagic fever

Mark G Kortepeter1, Daniel G Bausch, Mike Bray

  • 1Department of Preventive Medicine, Infectious Disease Clinical Research Program, Uniformed Services University of Health Sciences, Bethesda, Maryland 20814-5119, USA. mkortepeter@idcrp.org

The Journal of Infectious Diseases
|October 12, 2011
PubMed

Insights

Filoviruses like Marburg and Ebola cause severe hemorrhagic fever (HF). A review of outbreaks found limited clinical data, with no clear differences between filovirus infections except fatality rates.

Area of Science:

  • Virology
  • Infectious Diseases
  • Public Health

Background:

  • Filoviruses, including Marburg and Ebola viruses, are known to cause severe hemorrhagic fever (HF) in humans.
  • Since the first documented outbreak in 1967, numerous epidemics, individual cases, and laboratory-acquired infections have been reported globally.

Purpose of the Study:

  • To review and synthesize existing medical literature on filoviral hemorrhagic fevers.
  • To determine the fundamental clinical and laboratory characteristics of filoviral HF based on reported cases and outbreaks.

Main Methods:

  • A comprehensive review of published medical literature detailing filovirus outbreaks and infections.
  • Analysis of clinical and laboratory data from reported cases, with a focus on information from industrialized countries and specific African outbreaks.

Main Results:

  • Detailed clinical and laboratory data were more readily available from patients treated in industrialized nations.
  • Limited controlled or objective clinical data were found in reports from central African epidemics, with the exception of the 2000 Ebola Sudan outbreak in Uganda.
  • No significant differences in clinical features were observed among various filovirus infections, apart from case fatality rates.

Conclusions:

  • The compilation of clinical and laboratory features is valuable for healthcare professionals responding to filovirus epidemics.
  • This review identifies critical gaps in clinical data, guiding future research and the development of animal models for filoviral hemorrhagic fevers.

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