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Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection

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CVD graphene electrochemistry: biologically relevant molecules.

Dale A C Brownson¹, Maria Gómez-Mingot, Craig E Banks

¹Faculty of Science and Engineering, School of Science and the Environment, Division of Chemistry and Environmental Science, Manchester Metropolitan University, Chester Street, Manchester M1 5GD, Lancs, UK.

Physical Chemistry Chemical Physics : PCCP

|October 13, 2011

Summary

Chemical sensors using CVD-graphene show limited utility for detecting biological molecules. Surface

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Area of Science:

Electrochemistry
Materials Science
Biosensing

Background:

Chemical vapor deposition (CVD) grown graphene is explored for electrochemical sensing applications.
Graphene's unique properties make it a candidate for detecting biologically relevant analytes.

Purpose of the Study:

To investigate the electrochemical properties of CVD-graphene for detecting l-ascorbic acid (AA), dopamine hydrochloride (DA), β-nicotinamide adenine dinucleotide (NADH), uric acid (UA), and epinephrine (EP).
To determine the origin of the electrochemical response observed with CVD-graphene sensors.

Main Methods:

Electrochemical characterization of CVD-graphene.
Analysis of electrochemical responses to various biologically prevalent analytes.

Main Results:

The electrochemical response of CVD-graphene is primarily attributed to surface 'graphitic islands', not the graphene itself.
CVD-graphene exhibits electrochemical performance comparable to, or worse than, edge plane pyrolytic graphite (EPPG) electrodes.
Low oxygen-to-carbon (O/C) ratio likely contributes to suboptimal performance in some cases.

Conclusions:

CVD-graphene's electrochemical sensing capabilities for the studied analytes are limited by surface features rather than intrinsic graphene properties.
The presence of graphitic islands significantly influences the electrochemistry, mimicking EPPG electrodes.
Further research is needed to optimize CVD-graphene for reliable electrochemical biosensing.