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Polymorphism and solvatomorphism 2010.

Harry G Brittain¹

¹Center for Pharmaceutical Physics, Milford, New Jersey 08848, USA. hbrittain@centerpharmphysics.com

Journal of Pharmaceutical Sciences

|October 13, 2011

Summary

This review summarizes 2010 research on polymorphism and solvatomorphism, covering crystal structures and solvent inclusion in chemical compounds. It highlights computational, preparative, and characterization studies, including US patents.

Area of Science:

Solid-state chemistry
Crystallography
Materials science

Background:

Polymorphism involves different crystal structures of the same compound.
Solvatomorphism includes solvent molecules within crystal structures.
Understanding these phenomena is crucial for material properties and drug development.

Purpose of the Study:

To provide a comprehensive overview of polymorphism and solvatomorphism research published in 2010.
To consolidate findings from major scientific journals and patents.
To categorize and present advancements in the field.

Main Methods:

Literature review of scientific papers and patents from 2010.
Categorization of studies into general interest, computational, preparative, characterization, and phase transformation.

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Inclusion of US patents related to polymorphism and solvatomorphism.

Main Results:

A wide range of studies on crystal systems, including computational and experimental approaches.
Detailed characterization and property analysis of polymorphic and solvatomorphic forms.
Documentation of phase transformations and secondary processing effects.

Conclusions:

The field of polymorphism and solvatomorphism saw significant research activity in 2010.
Advancements were made in understanding, preparing, and characterizing these crystal systems.
The review serves as a valuable resource for researchers in solid-state chemistry and related fields.