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Related Experiment Video

Updated: May 28, 2026

18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor (SiFA) for Positron Emission Tomography

¹⁸F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor (SiFA) for Positron Emission Tomography

Published on: January 11, 2020

Cryptate mediated nucleophilic 18F-fluorination without azeotropic drying.

S H Wessmann¹, G Henriksen, H-J Wester

¹Chair of Pharmaceutical Radiochemistry, Technische Universität München, Munich, Germany.

Nuklearmedizin. Nuclear Medicine

|October 13, 2011

Summary

This summary is machine-generated.

This study simplifies 18F-radiotracer production by using a strong anion-exchange (SAX) resin to dry [18F]fluoride. This method yields reactive [K(+)⊂2.2.2]18F(-) comparable to traditional techniques, facilitating automated radiopharmaceutical synthesis.

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Radiosynthesis of 1-(2-[18F]Fluoroethyl)-L-Tryptophan using a One-pot, Two-step Protocol

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18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor (SiFA) for Positron Emission Tomography

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Microwave-assisted One-pot Synthesis of N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB)

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Radiosynthesis of 1-(2-[18F]Fluoroethyl)-L-Tryptophan using a One-pot, Two-step Protocol

Radiosynthesis of 1-(2-[¹⁸F]Fluoroethyl)-L-Tryptophan using a One-pot, Two-step Protocol

Published on: September 21, 2021

Area of Science:

Radiochemistry
Nuclear Medicine
Organic Synthesis

Background:

Radiosynthesis of 18F-labeled tracers typically involves azeotropic drying of [18F]fluoride.
This process is often complex and can be a bottleneck in radiopharmaceutical production.

Purpose of the Study:

To develop a simplified method for preparing reactive [18F]fluoride for nucleophilic substitution.
To enable efficient radiosynthesis of 18F-labeled tracers.

Main Methods:

Aqueous [18F]fluoride was trapped on a strong anion-exchange (SAX) cartridge.
The cartridge was washed with dry acetonitrile (CH3CN), and water-free [18F]fluoride was eluted using an anhydrous solution of [K(+)⊂2.2.2]OH(-) in CH3CN.

Main Results:

Quantitative retention of [18F]fluoride on the SAX cartridge was achieved.
Water-free [18F]fluoride was recovered in an overall yield of 92±5%.
Radiochemical yields of 70-90% were obtained for various 18F-tracers, including [18F]FDG, [18F]FET, and [18F]FLT.

Conclusions:

SAX-resin adsorbed [18F]fluoride can be effectively dried and eluted for radiolabeling.
The reactivity of the generated [K(+)⊂2.2.2]18F(-) is comparable to that obtained via azeotropic drying.
This procedure simplifies automated production of 18F-radiopharmaceuticals and microfluidic device applications.