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Mitral Valve Prolapse I: Introduction

IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
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Related Experiment Video

Updated: May 28, 2026

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

Intrinsic biventricular dysfunction in Marfan syndrome.

Piet de Witte1, Jan J J Aalberts, Teodora Radonic

  • 1Department of Cardiology, Academic Medical Center, Amsterdam, the Netherlands. p.dewitte@amc.uva.nl

Heart (British Cardiac Society)
|October 13, 2011
PubMed
Summary

Marfan syndrome (MFS) patients exhibit impaired biventricular function, independent of aortic elasticity or beta-blocker use. This suggests intrinsic myocardial dysfunction in MFS, with strong correlation between left and right ventricular ejection fractions.

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Biological Preparation and Mechanical Technique for Determining Viscoelastic Properties of Zonular Fibers
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Last Updated: May 28, 2026

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

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Published on: June 14, 2016

Biological Preparation and Mechanical Technique for Determining Viscoelastic Properties of Zonular Fibers
06:39

Biological Preparation and Mechanical Technique for Determining Viscoelastic Properties of Zonular Fibers

Published on: December 16, 2021

Area of Science:

  • Cardiology
  • Genetics
  • Medical Imaging

Background:

  • Marfan syndrome (MFS) is an inherited connective tissue disorder.
  • Mutations in the fibrillin-1 gene (FBN1) are common in MFS.
  • Fibrillin-1 is crucial for extracellular matrix integrity, affecting myocardial and vascular function.

Purpose of the Study:

  • To assess biventricular function in MFS patients.
  • To investigate the influence of aortic elasticity on ventricular function in MFS.
  • To evaluate the impact of beta-blocker treatment on cardiac function in MFS.

Main Methods:

  • Cardiac MRI was used to evaluate 144 MFS patients.
  • Biventricular systolic and diastolic volumes and ejection fractions were measured.
  • Aortic elasticity was assessed using flow wave velocity in the ascending aorta.

Main Results:

  • Impaired left ventricular ejection fraction (LVEF) and right ventricular ejection fraction (RVEF) were observed in MFS patients compared to controls.
  • LVEF and RVEF were strongly correlated (r = 0.7).
  • No significant correlation was found between aortic elasticity and LVEF, nor differences based on beta-blocker treatment.

Conclusions:

  • Biventricular ejection fraction is impaired in Marfan syndrome.
  • This impairment appears to be intrinsic myocardial dysfunction, independent of aortic elasticity.
  • Strong correlation between LVEF and RVEF suggests coordinated ventricular dysfunction.