Aortic Function in a Longitudinal 4D Flow MRI Study in Marfan Syndrome Patients Receiving Resveratrol

Area of Science:

• Cardiovascular Research
• Medical Imaging
• Pharmacology

Background:

• Marfan syndrome (MFS) necessitates novel strategies to mitigate aortic complications.
• Resveratrol, a dietary supplement, influences aortic wall cellular metabolism and may offer benefits to MFS patients.

Purpose of the Study:

• To investigate the impact of Resveratrol treatment on aortic hemodynamics in Marfan syndrome (MFS) patients using 4D flow MRI.

Main Methods:

• A prospective, single-arm, open-label, multicenter trial involving 46 MFS patients and 25 healthy controls.
• 4D flow MRI and 3D mDixon sequences were employed to assess hemodynamic parameters and aortic growth.
• Statistical analysis included t-tests, Fisher's exact tests, and Pearson correlation coefficients.

Main Results:

• One year of daily Resveratrol (500 mg) did not yield significant changes in aortic wall shear stress (WSS), velocity, or pulse wave velocity (PWV) in MFS patients.
• No significant differences were observed in the incidence of abnormally directed WSS between baseline and follow-up.
• Pulse wave velocity (PWV) showed a correlation with age in MFS patients with a history of aortic root surgery.

Conclusions:

• Resveratrol treatment for one year did not demonstrate significant effects on aortic hemodynamics in Marfan syndrome patients as evaluated by 4D flow MRI.
• The findings suggest that Resveratrol, at the tested dosage and duration, may not be an effective intervention for improving aortic hemodynamics in MFS.