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Updated: May 28, 2026
11:52
Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro
Published on: April 21, 2023
1-hexyl-2-cyanoacrylate compound (Neucrylate) bactericidal properties
Peter Friedman1, Violeta Casillas, Charles W Kerber
1Valor Medical Inc, San Diego, California 92121, USA. pfriedman@valormedical.com
Journal of Neurointerventional Surgery
|October 13, 2011
Summary
This study investigated Neucrylate, a modified cyanoacrylate tissue adhesive, for its antibacterial properties. Neucrylate demonstrated significant effectiveness against gram-positive bacteria, suggesting potential for infection prevention in medical devices.
Area of Science:
- Biomaterials Science
- Microbiology
- Medical Device Development
Background:
- Medical-grade tissue adhesives are crucial for surgery and trauma care.
- A modified cyanoacrylate (Neucrylate) was developed as an intravascular embolic agent.
- There is a need for implantable medical devices that inhibit hospital-acquired infections.
Purpose of the Study:
- To evaluate the antibacterial efficacy of Neucrylate.
- To determine Neucrylate's impact on common bacterial strains.
Main Methods:
- Seven common bacterial cultures were grown.
- Bacteria were exposed to Neucrylate.
- Microscopic and fluorescence analyses assessed the impact on bacteria.
Main Results:
- Neucrylate exhibited a strong antibacterial effect against gram-positive bacteria.
- A modest antibacterial effect was observed against gram-negative bacteria.
Conclusions:
- Neucrylate possesses significant antibacterial properties against gram-positive bacteria.
- Further research may explore Neucrylate's potential in preventing infections associated with medical devices.
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