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Esophagitis in children with celiac disease

Wael N Sayej1, Razan Alkhouri, Robert D Baker

  • 1Digestive Diseases, Hepatology and Nutrition Center, Connecticut Children's Medical Center, School of Medicine University of Connecticut, Framington, CT 06030, USA.

ISRN Gastroenterology
|October 13, 2011
PubMed

Insights

Esophagitis is common in children with celiac disease (CD), occurring in 39% of those diagnosed. This prevalence is similar to children without CD, suggesting no direct link.

Area of Science:

  • Pediatric Gastroenterology
  • Gastrointestinal Pathology

Background:

  • Celiac disease (CD) is an autoimmune disorder triggered by gluten.
  • Esophagitis, or inflammation of the esophagus, is a known gastrointestinal condition.
  • The relationship between CD and esophagitis in pediatric populations remains under-investigated.

Purpose of the Study:

  • To determine the prevalence of esophagitis in children diagnosed with celiac disease.
  • To compare esophagitis rates in children with CD versus those without CD.

Main Methods:

  • Retrospective review of biopsy-confirmed pediatric CD cases (2003-2007).
  • Analysis of esophageal inflammation from biopsy reports.
  • Comparison with esophagitis rates from 2218 general upper endoscopies during the same period.

Main Results:

  • Thirty-nine percent (19/49) of children with CD exhibited esophagitis.
  • Esophagitis prevalence in CD patients (39%) was not significantly different from non-CD patients (45%).
  • Higher prevalence observed in girls (46%) compared to boys (30%) with CD.

Conclusions:

  • No significant difference in esophagitis prevalence was found between children with CD and those without.
  • Further prospective studies are needed to explore treatment options for esophagitis in pediatric CD patients.

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