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Esophagitis in children with celiac disease
Wael N Sayej1, Razan Alkhouri, Robert D Baker
1Digestive Diseases, Hepatology and Nutrition Center, Connecticut Children's Medical Center, School of Medicine University of Connecticut, Framington, CT 06030, USA.
Esophagitis is common in children with celiac disease (CD), occurring in 39% of those diagnosed. This prevalence is similar to children without CD, suggesting no direct link.
Area of Science:
- Pediatric Gastroenterology
- Gastrointestinal Pathology
Background:
- Celiac disease (CD) is an autoimmune disorder triggered by gluten.
- Esophagitis, or inflammation of the esophagus, is a known gastrointestinal condition.
- The relationship between CD and esophagitis in pediatric populations remains under-investigated.
Purpose of the Study:
- To determine the prevalence of esophagitis in children diagnosed with celiac disease.
- To compare esophagitis rates in children with CD versus those without CD.
Main Methods:
- Retrospective review of biopsy-confirmed pediatric CD cases (2003-2007).
- Analysis of esophageal inflammation from biopsy reports.
- Comparison with esophagitis rates from 2218 general upper endoscopies during the same period.
Main Results:
- Thirty-nine percent (19/49) of children with CD exhibited esophagitis.
- Esophagitis prevalence in CD patients (39%) was not significantly different from non-CD patients (45%).
- Higher prevalence observed in girls (46%) compared to boys (30%) with CD.
Conclusions:
- No significant difference in esophagitis prevalence was found between children with CD and those without.
- Further prospective studies are needed to explore treatment options for esophagitis in pediatric CD patients.
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