Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...

Peptic Ulcer

Peptic Ulcer

Peptic ulcers are erosive lesions of the gastric or duodenal lining, most commonly caused by Helicobacter pylori infection. This Gram-negative, helical bacterium has adapted to survive the stomach’s acidic environment by producing urease, which converts urea into ammonia and carbon dioxide. The ammonia neutralizes gastric acid in the bacterium’s immediate environment, allowing colonization of the gastric mucosa. H. pylori attaches to mucus-secreting epithelial cells, penetrates the mucus...

Other Disorders of Digestive System

Other Disorders of Digestive System

The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...

Esophageal Achalasia

Esophageal Achalasia

Esophageal achalasia is a chronic neurogenic disorder characterized by impaired relaxation of the lower esophageal sphincter (LES) and absent or ineffective peristalsis in the distal esophagus. This leads to a functional obstruction without a physical blockage, despite significant disruption of esophageal motility.EtiologyAchalasia is caused by degeneration of the myenteric (Auerbach's) plexus, specifically the loss of inhibitory ganglion cells that produce vasoactive intestinal peptide (VIP)...

Inflammatory Bowel Disease I: Introduction

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...

Gastritis II: Pathophysiology

Gastritis II: Pathophysiology

The pathophysiology of gastritis begins with the colonization of the stomach lining by Helicobacter pylori (H. pylori). This bacterium spreads mainly via the oral-oral route through saliva or shared utensils, and can also be transmitted in overcrowded or unhygienic environments through contaminated water, despite its brief survival outside the body.ColonizationOnce ingested, H. pylori enters the stomach and begins colonization by navigating through the mucus layer lining the stomach wall. It...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Abstracts of the 2nd Congress of Clinical Physiology.

La Tunisie medicale·2026

Same author

Upper limb movement quality measures: comparing IMUs and optical motion capture in stroke patients performing a drinking task.

Frontiers in digital health·2024

Same author

Long term persistence and risk factors for anorectal symptoms following low anterior resection for rectal cancer.

BMC gastroenterology·2024

Same author

[Trichilemmal cyst of the eyelid: Clinical and histological features].

Journal francais d'ophtalmologie·2023

Same author

Isolated congenital osteoma cutis of the lateral canthus.

Journal francais d'ophtalmologie·2022

Same author

[Orbital tumor secondary to systemic sarcoidosis].

Journal francais d'ophtalmologie·2021

Same journal

Prescreening with FOBT Improves Yield and Is Cost-Effective in Colorectal Screening in the Elderly.

ISRN gastroenterology·2014

Same journal

Is CT Angiogram of the Abdominal Vessels Needed following the Diagnosis of Ischemic Colitis? A Multicenter Community Study.

ISRN gastroenterology·2014

Same journal

Predictors of Mortality among United States Veterans with Human Immunodeficiency Virus and Hepatitis C Virus Coinfection.

ISRN gastroenterology·2014

Same journal

A comparison of outcomes for adults and children undergoing resection for inflammatory bowel disease: is there a difference?

ISRN gastroenterology·2014

Same journal

Meckel's Diverticulum: Factors Associated with Clinical Manifestations.

ISRN gastroenterology·2014

Same journal

Study on the Biological Characteristics of CD133 (+) Cells Interfered by RNA Interference in Gastric Cancer.

ISRN gastroenterology·2014

See all related articles

Search research articles

Related Experiment Video

Updated: May 28, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

Digestive malacoplakia in children: case report.

J Bouguila¹, K Brahim, M Mokni

¹Paediatrics Department, Hospital Farhat Hached, 4000 Ibn El Jazzar Street, Sousse, Tunisia.

ISRN Gastroenterology

|October 13, 2011

Summary

This summary is machine-generated.

Pediatric intestinal malacoplakia, a rare inflammatory condition, was diagnosed in a 9-year-old girl presenting with abdominal pain and diarrhea. Successful treatment with oral levofloxacin highlights the importance of histological confirmation for this elusive disease.

Related Experiment Videos

Last Updated: May 28, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

Area of Science:

Gastroenterology
Pediatric Pathology
Inflammatory Diseases

Background:

Malacoplakia is a rare chronic granulomatous inflammatory condition.
The gastrointestinal tract is the second most frequent site affected by malacoplakia.
Pediatric cases of malacoplakia are exceptionally uncommon.

Observation:

A 9-year-old girl presented with significant gastrointestinal distress, including abdominal pain, chronic diarrhea, and rectal hemorrhage.
Diagnostic procedures involved endoscopic examinations and histopathological analysis.
These investigations confirmed the presence of intestinal malacoplakia.

Findings:

Histopathology is the definitive diagnostic method for intestinal malacoplakia.
The condition lacks specific clinical or biological markers, making diagnosis challenging.
The patient's symptoms were successfully managed with oral levofloxacin.

Implications:

This case underscores the importance of considering malacoplakia in pediatric patients with unexplained gastrointestinal symptoms.
Accurate histological diagnosis is crucial for effective management of intestinal malacoplakia.
Levofloxacin represents a viable therapeutic option for pediatric intestinal malacoplakia.