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Related Concept Videos

Post-traumatic Stress Disorder01:27

Post-traumatic Stress Disorder

Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events, are a...
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
Traumatic Memory01:20

Traumatic Memory

Emotionally traumatic events often lead to memories that are exceptionally vivid and enduring, sometimes persisting with remarkable clarity throughout an individual's life. A classic example of this phenomenon is a person who survives a car accident. Even years later, they may recall every detail of the event with startling accuracy — the screeching of the tires, the jarring impact, and the acrid smell of burning rubber. Such vividness contrasts sharply with how an individual remembers mundane...
Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which forms a...

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Polar Histogram Visualization of Acute Stress Disorder Scale Scores for Comprehensive Clinical Assessment
08:25

Polar Histogram Visualization of Acute Stress Disorder Scale Scores for Comprehensive Clinical Assessment

Published on: December 6, 2024

Hypercoagulation in chronic post-traumatic stress disorder.

Odile Robicsek1, Badira Makhoul, Ehud Klein

  • 1Department of Psychiatry, Rambam Health Care Campus affiliated to Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel. odilerobicsek@yahoo.com

The Israel Medical Association Journal : IMAJ
|October 14, 2011
PubMed
Summary
This summary is machine-generated.

Chronic stress, like post-traumatic stress disorder (PTSD), elevates hypercoagulation. Severe PTSD shows increased von Willebrand factor (vWF) and factor VIII, suggesting endothelial activation contributes to thromboembolic risk.

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Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)
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Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)

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Related Experiment Videos

Last Updated: May 28, 2026

Polar Histogram Visualization of Acute Stress Disorder Scale Scores for Comprehensive Clinical Assessment
08:25

Polar Histogram Visualization of Acute Stress Disorder Scale Scores for Comprehensive Clinical Assessment

Published on: December 6, 2024

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)
04:56

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)

Published on: August 4, 2023

Area of Science:

  • Cardiovascular Science
  • Hematology
  • Psychiatry

Background:

  • Mechanisms of hypercoagulation in chronic stress, particularly post-traumatic stress disorder (PTSD), remain unclear.
  • Chronic coagulation disturbances are linked to increased morbidity and mortality from thromboembolism and cardiovascular disorders in PTSD patients.

Purpose of the Study:

  • To investigate the mechanisms underlying hypercoagulation in individuals with chronic PTSD.

Main Methods:

  • Thirty chronic PTSD patients and a control group were assessed for coagulation parameters including fibrinogen, D-dimer, prothrombin fragment F 1+2, von Willebrand factor (vWF) antigen, and factor VIII activity.
  • Psychiatric severity was evaluated using the Mini-International Neuropsychiatric Interview and Clinician Administered PTSD Scale (CAPS).

Main Results:

  • Patients with chronic PTSD exhibited significantly higher levels of vWF antigen compared to controls.
  • Severe chronic PTSD (CAPS > 80) was associated with elevated vWF antigen and factor VIII activity compared to controls and less severe PTSD cases.
  • No significant differences in other tested coagulation parameters were observed between groups.

Conclusions:

  • Severe chronic PTSD is characterized by increased vWF antigen and factor VIII activity.
  • These findings suggest that endothelial damage or activation may contribute to the heightened risk of arterial and venous thromboembolic events in PTSD patients.