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Related Experiment Video

Updated: May 28, 2026

Isolation of Basal Cells and Submucosal Gland Duct Cells from Mouse Trachea

Isolation of Basal Cells and Submucosal Gland Duct Cells from Mouse Trachea

Published on: September 14, 2012

Tracheal telocytes.

M C Rusu¹, Adelina M Jianu, N Mirancea

¹Division of Anatomy, Faculty of Dental Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.

Journal of Cellular and Molecular Medicine

|October 14, 2011

Summary

This summary is machine-generated.

Telocytes (TC), a novel stromal cell type, were identified in the mouse trachea, potentially regulating airway functions. Further research is needed on the TC-mast cell interactions within the trachea.

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Isolation of Basal Cells and Submucosal Gland Duct Cells from Mouse Trachea

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Published on: September 14, 2012

Isolation and Quantitative Evaluation of Brush Cells from Mouse Tracheas

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Isolation of Murine Intestinal Mesenchyme Resulting in a High Yield of Telocytes

Isolation of Murine Intestinal Mesenchyme Resulting in a High Yield of Telocytes

Published on: March 24, 2023

Area of Science:

Cell Biology
Histology
Respiratory System

Background:

Telocytes (TC) are a recently identified stromal cell type known for intercellular signaling.
The presence and function of TC in the trachea have not been previously established.

Purpose of the Study:

To identify and characterize telocytes (TC) in the mouse trachea.
To investigate the potential role of TC in tracheal regulation and intercellular communication.

Main Methods:

Immunohistochemistry and electron microscopy were used to identify and visualize TC in mouse tracheal tissue.
Ultrastructural analysis was performed to examine the morphology and connections of TC and associated cells.

Main Results:

Telocytes (TC) were found throughout all stromal compartments of the mouse tracheal wall.
TC possess long prolongations (telopodes) that form serial end-to-end arrangements and establish stromal synapses with mast cells (MC).
Primary cilia were identified on TC.

Conclusions:

Tracheal telocytes (TC) may play a role in regulating tracheal functions such as secretion and contractility.
The newly identified TC-mast cell (MC) network in the trachea warrants further investigation for its functional significance.