Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 28, 2026

Treatment of Ligament Constructs with Exercise-conditioned Serum: A Translational Tissue Engineering Model
08:03

Treatment of Ligament Constructs with Exercise-conditioned Serum: A Translational Tissue Engineering Model

Published on: June 11, 2017

Tissue engineering bone-ligament complexes using fiber-guiding scaffolds.

Chan Ho Park1, Hector F Rios, Qiming Jin

  • 1Department of Biomedical Engineering, University of Michigan College of Engineering, Ann Arbor, MI 48109, USA.

Biomaterials
|October 14, 2011
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

EP4 agonist KMN-159 induces osteogenesis in rodent and porcine dental models.

Bone·2026
Same author

Thermal Post-Processing of 3D-Printed Poly(glycerol dodecanedioate) Controls Mechanics and Shape Memory Properties.

Polymer science & technology (Washington, D.C.)·2026
Same author

A 3D-Printed Scaffolded Hydrogel Microneedle Array Biosensor for Real-Time, Continuous Monitoring.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

A bibliometric and altmetric analysis of global research trends on intraoral scanners in digitally assisted dentistry.

The Journal of prosthetic dentistry·2026
Same author

Clinical, Histomorphometric, and Digital Evaluation of Plasma Rich in Growth Factors for Alveolar Ridge Preservation: A Randomized Controlled Clinical Trial.

The International journal of oral & maxillofacial implants·2026
Same author

Peri-Implantitis and Periodontitis: Biological Convergence, Contextual Divergence.

Journal of periodontal research·2026

This study introduces novel fiber-guiding scaffolds to regenerate bone-ligament complexes. These biomimetic scaffolds promote organized tissue integration for functional restoration after injury.

Area of Science:

  • Biomaterials Engineering
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Regenerating bone-ligament complexes is clinically challenging due to intricate tissue integration requirements.
  • Current methods for reconstructing soft-hard tissue interfaces have limited success.
  • Restoring functional osseous defects requires precise tissue architecture.

Purpose of the Study:

  • To develop and evaluate biomimetic fiber-guiding scaffolds for bone-ligament regeneration.
  • To assess the efficacy of custom-fit scaffolds in guiding functionally-oriented ligamentous fibers in vivo.
  • To compare the performance of fiber-guiding scaffolds against traditional scaffolds for tissue integration.

Main Methods:

  • Solid free-form fabrication was used to create custom-fit, biomimetic scaffolds.

More Related Videos

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization
09:32

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

Published on: April 19, 2015

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

Related Experiment Videos

Last Updated: May 28, 2026

Treatment of Ligament Constructs with Exercise-conditioned Serum: A Translational Tissue Engineering Model
08:03

Treatment of Ligament Constructs with Exercise-conditioned Serum: A Translational Tissue Engineering Model

Published on: June 11, 2017

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization
09:32

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

Published on: April 19, 2015

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

  • Scaffolds featured perpendicularly oriented micro-channels to guide cellular processes.
  • Cell transplantation into hybrid scaffolding constructs was performed to assess tissue organization.

    • Main Results:

    • Fiber-guiding scaffolds demonstrated superior guidance for ligamentous fiber anchoring.
    • The developed scaffolds successfully restored large osseous defects under biomechanical loading.
    • Cell transplantation with guidance channels led to predictable fiber architecture and enhanced ligament interface organization.

    Conclusions:

    • Biomimetic fiber-guiding scaffolds effectively drive neogenesis of triphasic bone-ligament integration.
    • These scaffolds offer improved control over tissue infiltration and organization compared to random architectures.
    • The findings support the potential of fiber-guiding scaffolds for diverse clinical applications in bone and ligament repair.