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Virus-associated Trichodysplasia spinulosa.

Belinda H Tan¹, Klaus J Busam

¹Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. belindat@gmail.com

Advances in Anatomic Pathology

|October 14, 2011

Summary

This review covers virus-associated trichodysplasia spinulosa (TS), a skin condition linked to the new human TS polyomavirus. It highlights how clinicopathologic and molecular genetic methods reveal insights into this emerging dermatologic diagnosis.

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Published on: October 17, 2012

Area of Science:

Dermatology
Virology
Pathology

Background:

Emerging dermatologic entity: virus-associated trichodysplasia spinulosa (TS).
Association with the novel human TS polyomavirus.
Distinct diagnosis arising from converging histopathologic findings.

Purpose of the Study:

Discuss the evolution of virus-associated TS.
Describe the emergence of this distinct dermatologic diagnosis.
Illustrate the role of clinicopathologic and molecular genetic approaches in understanding cutaneous disease pathogenesis.

Main Methods:

Review of case reports with similar histopathologic findings.
Analysis of the association with human TS polyomavirus.
Integration of clinicopathologic observation and molecular genetic insights.

Main Results:

Identification of virus-associated TS as an emerging dermatologic entity.
Establishment of a link between TS and human TS polyomavirus.
Demonstration of shared histopathologic features across multiple cases.

Conclusions:

Virus-associated TS is an evolving dermatologic diagnosis.
The human TS polyomavirus is implicated in the pathogenesis of TS.
Combined clinicopathologic and molecular genetic studies are crucial for understanding cutaneous diseases.