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Seroconversion to HCoV-NL63 in Rhesus Macaques.

Ronald Dijkman1, H Lie Mulder, Lynne Rumping

  • 1Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity (CINIMA), Academic Medical Centre (AMC), University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands; E-Mails: r.dijkman@amc.uva.nl (R.D.); h.l.mulder.1@student.rug.nl (H.L.M.); lynne.rumping@student.uva.nl (L.R.); ilse.kraaijvanger@student.uva.nl (I. K.); m.deijs@amc.uva.nl (M.D.); m.f.jebbink@amc.uva.nl (M.F.J.).

Viruses
|October 14, 2011
PubMed
Summary

Human coronavirus NL63 (HCoV-NL63) infections were studied in rhesus macaques. Antibody analysis revealed evidence of natural HCoV-NL63 infection in three long-term study animals.

Keywords:
HCoV-NL63rhesus macaques

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Area of Science:

  • Virology
  • Infectious Diseases
  • Primate Models

Background:

  • Human coronavirus NL63 (HCoV-NL63) is a respiratory virus.
  • The pathogenesis of HCoV-NL63 remains unclear due to the absence of a suitable animal model.

Purpose of the Study:

  • To investigate the occurrence of HCoV-NL63 infections in rhesus macaques.
  • To establish if rhesus macaques can serve as a model for studying HCoV-NL63 infection.

Main Methods:

  • Longitudinal monitoring of antibody levels against HCoV-NL63 in rhesus macaques.
  • Study duration ranged from 7 to 19 years.

Main Results:

  • A significant increase in HCoV-NL63 antibodies was observed in three macaques during the follow-up period.
  • This rise in antibody titers suggests natural HCoV-NL63 infection occurred in these animals.

Conclusions:

  • Rhesus macaques exhibit natural infections with HCoV-NL63.
  • These findings support the potential use of rhesus macaques as an animal model for HCoV-NL63 pathogenesis research.