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Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
Published on: September 16, 2011
NSAID-sensitive antihistamine-induced urticaria/angioedema
S Cimbollek1, M Ortega Camarero, R Avila
1Allergy Department, Hospital Virgen del Rocío, Seville, Spain. scimbollek@gmail.com
Journal of Investigational Allergology & Clinical Immunology
|October 15, 2011
Summary
This study details a rare case of antihistamine-induced urticaria in a patient with nonsteroidal anti-inflammatory drug (NSAID) sensitivity. Researchers identified a specific subset of antihistamine urticaria linked to NSAID sensitivity.
Area of Science:
- Allergy and Immunology
- Pharmacology
- Dermatology
Background:
- Nonsteroidal anti-inflammatory drug (NSAID) sensitivity can manifest as hypersensitivity reactions.
- Urticaria and angioedema are common allergic reactions, but drug-induced cases require careful diagnosis.
Observation:
- A patient with NSAID sensitivity experienced immediate generalized urticaria with ibuprofen and naproxen.
- Delayed urticarial reactions were noted after previous oral antihistamine use.
- Skin tests for loratadine and cetirizine were negative, but oral challenge with loratadine induced urticaria.
Findings:
- The patient developed urticaria and angioedema after a placebo-controlled oral challenge with piroxicam.
- A subsequent oral challenge with loratadine resulted in generalized urticaria.
- Fexofenadine was tolerated, suggesting specific antihistamine sensitivities.
Implications:
- This case suggests a potential new subset of antihistamine-induced urticaria.
- The condition is termed NSAID-sensitive antihistamine-induced urticaria/angioedema.
- Further research is needed to understand the mechanisms and prevalence of this specific drug hypersensitivity.
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