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Expedient synthesis of chiral homoallylamines via N,O-acetal TMS ethers and its application

Young-Ger Suh1, Jaebong Jang, Hwayoung Yun

  • 1College of Pharmacy, Seoul National University, Seoul 151-742, Korea. ygsuh@snu.ac.kr

Organic Letters
|October 15, 2011
PubMed

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Introduction
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Preparation of 1° Amines: Gabriel Synthesis

Direct alkylation is not a suitable method for synthesizing amines because it produces polyalkylated products. Gabriel synthesis is the most preferred method to exclusively make primary amines. The method uses phthalimide, which contains a protected form of nitrogen that participates in alkylation only once to predominantly give primary amines.
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Amines to Amides: Acylation of Amines

Various carboxylic acid derivatives (such as acid chlorides, esters, and anhydrides) can be used for the acylation of amines to yield amides. The reaction requires two equivalents of amines. The first amine molecule functions as a nucleophile and attacks the carbonyl carbon to produce a tetrahedral intermediate. This is followed by the loss of the leaving group and restoration of the C=O bond.
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Synthesis of α-Substituted Carbonyl Compounds: The Stork Enamine Reaction

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