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Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

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Related Experiment Video

Updated: May 28, 2026

Surgical Approach to Full Soft Tissue Face Allograft Procurement for Vascularized Composite Allotransplantation

Surgical Approach to Full Soft Tissue Face Allograft Procurement for Vascularized Composite Allotransplantation

Published on: December 30, 2025

Face transplantation: a leading surgeon's perspective.

¹Department of Plastic Surgery, The Cleveland Clinic, Cleveland, Ohio 44195, USA. siemiom@ccf.org

Transplantation Proceedings

|October 15, 2011

Summary

This study details twenty years of experience in vascularized composite allografts (VCA), culminating in the first US face transplantation. It covers protocol development, regulatory hurdles, and the crucial multidisciplinary team approach for successful outcomes.

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Last Updated: May 28, 2026

Surgical Approach to Full Soft Tissue Face Allograft Procurement for Vascularized Composite Allotransplantation

Surgical Approach to Full Soft Tissue Face Allograft Procurement for Vascularized Composite Allotransplantation

Published on: December 30, 2025

Facial Transplants in Xenopus laevis Embryos

Facial Transplants in Xenopus laevis Embryos

Published on: March 26, 2014

An Experimental Human DIEP Flap Model to Investigate Preservation Strategies for Vascularized Composite Allografts and Free Flaps

An Experimental Human DIEP Flap Model to Investigate Preservation Strategies for Vascularized Composite Allografts and Free Flaps

Published on: December 5, 2025

Area of Science:

Surgical innovation in reconstructive transplantation.
Advancements in vascularized composite allografts (VCA).

Background:

Presents twenty years of research and development in VCA.
Highlights the progression towards complex facial allotransplantation.

Observation:

Outlines experimental and cadaveric VCA models.
Details the development of a face transplantation protocol and IRB approval process.

Findings:

Discusses scientific, regulatory, and financial considerations for face transplantation.
Emphasizes the critical role of a multidisciplinary team.

Implications:

Covers technical aspects of face transplantation.
Reports on immunologic and functional patient outcomes.