Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Biological Effects of Radiation02:59

Biological Effects of Radiation

All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they produce ions...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
Radiation: Applications01:17

Radiation: Applications

The average temperature of Earth is the subject of much current discussion. Earth is in radiative contact with both the Sun and dark space; it receives almost all its energy from the radiation of the Sun and reflects some of it into outer space. Dark space is very cold, about 3 K, so Earth radiates energy into it. For instance, heat transfer occurs from soil and grasses, the rate of which can be so rapid that frost can occur on clear summer evenings, even in warm latitudes.
The average...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real-world outcomes of definitive chemoradiotherapy for bladder cancer: a multi-institutional retrospective study in Japan.

Japanese journal of clinical oncology·2026
Same author

Diabetes mellitus as a potential risk factor for severe late toxicity after stereotactic body radiotherapy for prostate cancer: a large single-institution cohort study.

Journal of radiation research·2026
Same author

Beam-axis stability during gantry rotation measured with scintillation dosimetry.

Journal of applied clinical medical physics·2026
Same author

Safety and efficacy of moderately hypofractionated radiotherapy after radical prostatectomy: A phase II trial.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2026
Same author

Comparison of small bowel and bladder doses between prone and supine positions in preoperative intensity-modulated radiotherapy for rectal cancer.

Radiological physics and technology·2026
Same author

Definitive radiotherapy for early stage glottic cancer: a quarter-century of single-institution experience with long-term outcomes and late events.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·2026

Related Experiment Videos

[Radiotherapy for Japanese elderly patients].

Hideomi Yamashita1

  • 1Department of Radiology, University of Tokyo Hospital, Tokyo, Japan.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|October 15, 2011
PubMed
Summary

Radiotherapy (RT) significantly improves survival outcomes for elderly cancer patients. Curative RT offers a 75% 2-year survival rate, while palliative RT provides a 25% 1-year survival rate, demonstrating RT

Area of Science:

  • Geriatric Oncology
  • Radiation Oncology
  • Clinical Cancer Research

Context:

  • Elderly patients (>=80 years) represent a growing demographic in cancer care.
  • Radiotherapy (RT) is a cornerstone treatment modality for various cancer types.
  • Understanding RT efficacy and safety in the oldest cancer patients is crucial for treatment individualization.

Purpose:

  • To evaluate the survival outcomes of cancer patients aged 80 years and older treated with radiotherapy.
  • To compare survival rates based on the intent of radiotherapy (curative/semi-radical vs. palliative).

Summary:

  • Ninety-seven elderly cancer patients (>=80 years) receiving RT were analyzed.
  • Patients receiving RT with curative or semi-radical intent showed a 75% 2-year overall survival rate (n=64).

Related Experiment Videos

  • Patients receiving RT with palliative intent demonstrated a 25% 1-year overall survival rate (n=33).

    • Impact:

    • Radiotherapy is an effective and safe treatment option for elderly cancer patients.
    • RT can significantly improve survival in elderly individuals, regardless of treatment intent.
    • Findings support the consideration of RT in the geriatric oncology treatment paradigm.