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Updated: May 28, 2026

Nine-Grid Area Division Method: A New Ideal Bone Puncture Region for Percutaneous Vertebroplasty in Lumbar Spine
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Mortality in the vertebroplasty population.

R J McDonald1, S J Achenbach, E J Atkinson

  • 1Clinician Investigator Training Program, Department of Radiology, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA. mcdonald.robert@mayo.edu

AJNR. American Journal of Neuroradiology
|October 15, 2011
PubMed
Summary
This summary is machine-generated.

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Vertebroplasty for painful vertebral fractures shows similar survival to symptomatic untreated fractures. However, it is associated with worse survival compared to asymptomatic fractures.

Area of Science:

  • Orthopedics
  • Geriatric Medicine
  • Interventional Radiology

Background:

  • Vertebroplasty effectively treats painful vertebral compression fractures resistant to conservative care.
  • Limited data exists on the long-term survival of patients undergoing vertebroplasty.
  • Understanding mortality risk is crucial for patient selection and management.

Purpose of the Study:

  • To compare the survival rates of patients treated with vertebroplasty versus an untreated cohort.
  • To determine if vertebroplasty influences overall mortality in patients with vertebral compression fractures.

Main Methods:

  • A cohort of 524 vertebroplasty recipients was compared to 589 untreated historical controls.
  • Survival analysis used Cox proportional hazards models, adjusting for age, sex, and comorbidity.

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  • Internal analysis correlated procedural metrics with survival within the treated group.

    • Main Results:

    • Vertebroplasty patients had 77% of expected survival based on US population norms.
    • A 17% higher mortality risk was observed in vertebroplasty recipients compared to both symptomatic and asymptomatic untreated fractures.
    • After adjusting for confounders, vertebroplasty patients showed no increased mortality compared to symptomatic untreated fractures (HR 1.02).
    • No procedural or clinical efficacy metrics predicted survival outcomes.

    Conclusions:

    • Vertebroplasty recipients exhibit mortality rates comparable to those with symptomatic untreated vertebral fractures.
    • Mortality risk is higher in vertebroplasty recipients than in those with asymptomatic vertebral fractures.